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KMID : 0384320020230070917
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Korean Journal of Family Medicine
2002 Volume.23 No. 7 p.917 ~ p.924
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The Association of Abdominal Fat with Serum Insulin and Atherogenic Index for Obese Females
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Lee Ka-Young
Sohn Hae-Sook
Lee Nam-Su
Han Jung-Hee
Kim Ki-Jung
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Abstract
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Background: The purpose of this study was to find an independent relationship between waist circumference/waist-to-hip ratio which estimates abdominal fat and fasting insulin/atherogenic index which is a predictor of coronary heart disease in obese women.
Methods: The subjects were 80 obese (BMI≥25 kg/m2) women. Whole body fat was estimated by body fat mass, % body fat using bioelectrical impedence, and by BMI. Abdominal fat was measured by waist circumference (WC) and waist-to-hip ratio. Fasting insulin was examined and atherogenic index was defined asthe ratio of serum total cholesterol to HDL-cholesterol. Independent association between abdominal fat and insulin/AI was analyzed using partial correlation, multiple regression and Hotelling t-test.
Results: Among subjects, 85.7% of obese women had WC greater or equal to 80 cm. The mean BMI was 30.3 kg/m2. The partial correlations between whole body fat and insulin/AI were not significantly different from the partial correlations between abdominal fat and insulin/AI. When age and height were adjusted, partial correlations between abdominal fat and insulin were 0.38 and 0.39. The partial correlations were reduced to 0.15∼0.29 after further adjusting for whole body fat. Age and height-adjusted partial correlations between abdominal fat and AI were 0.34 and 0.36. The partial correlations were reduced to -0.11∼0.17 when whole body fat was additionally adjusted. Whole body fat explained 9.9∼13.7% for variability of insulin; abdominal fat explained 14.2% and 15.9%. Whole body fat explained 12.5∼12.8% for variability of AI and abdominal fat explained 11.9%.
Conclusion: Most of the obese women showed abdominal obesity. Abdominal fat did not seem to be independently associated with fasting insulin and atherogenic index.
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KEYWORD
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abdominal fat, obesity, women, fasting insulin, atherogenic index
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